芪黄汤加减内服外熏联合艾灸治疗2型糖尿病周围神经病变疗效及对血清MDA、ET-1水平的影响.docx

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1、黄黄汤加减内服外熏联合艾灸治疗2型糖尿病周围神经病变疗效及对血清MDA、ET7水平的影响张彦芬，王可可，郭浩楠，吴红群，徐彦娜商洛市中心医院中西医结合科，陕西商洛726000基金项目：陕西省科技攻关项目(编号：2010K21393)第一作者：张彦芬(1985-12),女，本科，主治医师，研究方向：中西医结合治疗糖尿 病神经病变通讯作者：徐彦娜(1989-11),女,硕士，主治医师，研究方向：中西医结合，E- mail：【摘要】目的 探讨芭黄汤加减内服外熏联合艾灸治疗2型糖尿病周围神经病变(DPN) 的疗效及对血清丙二醛(MDA)、内皮素-I(ET-I)水平的影响。方法 选择2021年2月 至2

2、022年12月商洛市中心医院接诊的160例DPN患者进行治疗，按照随机数表法分为观 察组和对照组，各80例，对照组给予常规处理及甲钻胺片治疗，观察组在对照组基础上， 联合黄黄汤加减内服外熏、艾灸治疗，两组患者均持续治疗4周。比较两组患者治疗4周后 的临床疗效，以及治疗前、治疗4周后正中神经、腓总神经的运动神经传导速度(MNCV)、 运动神经传导速度(MNCV),及多伦多临床评分系统(TCSS)评分、血清MDA、ET-I水 平的变化，以及治疗期间不良反应发生情况。结果 治疗后，观察组患者的临床疗效总有效 率为91.25%,明显高于对照组的76.25%,差异有统计学意义(P (48.124.69)

3、m/s、(44.293.46)ms,均明显高于对照组的(46.034.13) m/s、(43.193.84) m/s、(45.284.37) m/s、(41.734.11) ms,差异有统计学意义(PV 0.05)；观察组患者的TCSS评分、血清MDA、ET-I水平分别为(6.161.15)分、(4.180.62) nmolmL (65.127.63) mgL,均明显低于对照组的(7.381.34)分、(5.090.78) nmol/mL、 (78.11 9.04)mgL,有统计学意义(PV0.05)；两组治疗期间均无严重不良反应情况出现。结论 芭黄汤加减内服外熏联合艾灸治疗DPN患者的疗效显

4、著，可明显改善患者神经传导 速度，且能降低血清MDA、ET-I水平的表达，促进病情恢复，值得临床应用。【关键词】2型糖尿病；糖尿病周围神经病变；黄黄汤；艾灸；神经传导速度；丙二醛； 内皮素-1Effect of Qi Huang decoction plus or minus for oral and external fumigation combined withMoxibustion on type 2 diabetic peripheral neuropathy and its effect on serum MDA and ET- 1 levelsZHANG Yan-fen, WAN

5、G Ke-kef GUO Hao-nan, WU Hong-qun, XU Yan-naDepartment of Integrated Traditional Chinese and Western Medicine, The Central hospital of Shangluo City, Shangluo 726000, Shaanxi, CHINAAbstract Objective To study the effect of Qihuang decoction plus or minus for oral and external fumigation combined wit

6、h Moxibustion on type 2 diabetic peripheral neuropathy(DPN) and its effect on serum MaIondialdehyde(MDA)and Endothelin-I(ET-I) levels. Methods 160 patients with DPN treated in our hospital from FebrUary 2021 to December 2022 were selected for treatment, according to the random number table method, t

7、hey were divided into observation group and control group, with 80 cases in each group. The control group patients was treated with routine treatment and Mecobalamin tablets, on the basis of the control group, the observation group patients was combined with Qihuang decoction plus or minus for oral

8、and external fumigation, moxibustion, the patients in both groups were treated for 4 weeks. The clinical efficacy at after 4 treatmen weeks, the changes of motor nerve conduction velocity (MNCV) and motor nerve conduction velocity (MNCV) of median nerve and common peroneal nerve, the Toronto clinica

9、l scoring system (TCSS) scores, the serum MDA and ET-I levels at before treatment and after 4 treatmen weeks, and the occurrence of adverse reactions during treatment in two group patients were compared. Results After treatment, the total effective rate in the observation group was 91.25%, which was

10、 significantly higher than 76.25% of the control group, the difference was statistically significant (P0,05); after treatment, the MNCV of median nerve and common peroneal nerve and SNCV of median nerve and common peroneal nerve in observation group patients were (49.225.17) ms, (45.274.03) ms, (48.124.69) ms, (44.293.46) ms, which were significantly higher than the control group (46.034.13) ms, (43.193.84) ms, (45.284.37) ms, (41.734.11) ms, the differences were statistically significant (P0.05）,见表I0所有患者均签署研究知情 同意书，且研究已通过我院伦理委员会批准。表1两组一般资料比较由