(优质)最新综述-类风湿关节炎治疗进展-新药和治疗策略的分析Nature reviews Rheumatology.docx
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1、最新综述一类风湿关节炎治疗进展新药和治疗策略的分析 Nature reviews Rheumatology类风湿关节炎(RA )以多关节炎为主要病理表现,如果不进行适当的治疗,往往会造成不可逆的关节 结构损伤和多器官损伤。因此,及时有效的治疗是RA临床管理的重要环节。近年来,RA治疗模式不断转变。从甲氨蝶聆(MTX )等传统合成改善病情抗风湿药(CSDMARDs ), 到靶向肿瘤坏死因子(TNFX白介素(IL ) -6受体等靶点的生物制剂DMARDs ( bDMARDs ),以及靶向 合成DMARDs (tsDMARDs ),例如Janus激酶(JAK )抑制剂等小分子药物。由于这些新型药物的
2、引入, 临床缓解已成为RA患者可实现的治疗目标。近日,有学者针对RA领域可用的bDMARDs和tsDMARDs作系统综述,汇总各类药物进展,并就 未来的治疗策啷乍简要总结。Nature reviews Rheumatology ( Oxford ).(影响因子:7.58 nature reviews rheumatologyExplore content v About the journal v Publish with us vSubscribenature nature reviews rheumatOlOqy review articles articlePublished: MarC
3、h 2006Technology Insight: gene transfer and the design of novel treatments for rheumatoid arthritisFalk MoritZf OliVer Distler, CaroIine OSPeIL Renate E Gay & Steffen Gay 回NatUre QiniCal PraCtiCe RheUmasiogy 21 153-162 (2006) Cite this aticle872 Accesses 10 Citations MetriCSAbstractRheumatoid arthri
4、tis (RA) is a chronic inflammatory disease characterized by systemic inflammation and joint destruction. Novel therapies have emerged during the past decade, marking a new era in the treatment of RA. Meanwhile, in vivo and in vitro gene-transfer studies have provided valuable insights into mechanism
5、s of disease pathogenesis. Advanced genedelivery techniques and animal models promise further progress in RA research and the development of novel therapeutic strategies for this disease. In this article we provide an overview of the wide spectrum of potential targets that have been identified so fa
6、r, discuss currently available gene-transfer methods, and outline the barriers that need to be overcome for these approaches to be successfully applied in daily practice.Key PointsCytokines, activating factors of synovial cells, matrix-degrading enzymes and regulators of cell survival and apoptosis
7、have been characterized as potential therapeutic targets in rheumatoid arthritis (RA)Gene-transfer experiments in animal models have been useful for the identification of diseaserelevant moleculesThe severe combined immunodeficient mouse co-implantation model is currently the most informative model
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