ZetaPALS测量应用案例201623.docx

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1、ZetaPA1S测量应用案例-2016-23文献名：Preparation,characterizationandinvitrophotodynamictherapyofapyropheophorbide-a-conjugatedFe3O4mu1tifunctiona1magnetof1Uorescencephotosensitizer作者：JianjunCheng,aGuanghuiTan,abWenting1i/Jinghua1i,aZhiqiangWangaandYingxueJinaaKey1aboratoryforPhotonicandE1ectronicBandgapMateria

2、1s,MinistryofEducation,Co11egeofChemistry&Chemica1Engineering,HarbinNorma1University,Harbin,ChinabCo11egeof1ifeScienceandTechno1ogy,HarbinNorma1University,Harbin,China摘要：Nove1pyropheophorbide-a-conjugatedmu1tifunctiona1magnetof1uorescencenanopartic1esFe3O4SiO2APTESGIUtary1-PPa(MFNPs)withameandiamete

3、rof50nmwerestrategica11ydesignedandpreparedfrphotodynamictherapy(PDT)andmedica1f1uorescenceimaging.Ch1orinphotosensitizerpyropheophorbide-a(PPa)wascova1ent1yanchoredonthesurfaceofcore-she11Fe3O4SiO2APTESnanopartic1esthatwerepreparedviaaso1-ge1processwithabridgingg1utary1group.Thephaseconstitution,mo

4、rpho1ogy,size,chemica1properties,magneticpropertyoftheintermediatesandfina1nanopartic1eswerecharacterizedbyX-raypowderdiffraction,transmissione1ectronmicroscopy,Fouriertransforminfraredspectrometer,zetapotentia1,vibrationsamp1emagnetometer,thermogravimetricana1ysis,u1travio1et-visib1eabsorptionspect

5、raandf1uorescentemissionspectroscopy.Theseresu1tsshowedthattheMFNPshavegooddispersibi1ityina1coho1andwater,exce11entmagnetizationwith17.31emug-1at300K,strongSuperparamagneticandgoodphoto1uminescenceproperty.TheinvitroPDTagainstthehumanHe1acervica1cancerce11suggestedthatMFNPscou1dpermeatethetumorce11

6、squick1yandpossesssuitab1e1ipo-hydropartitioncoefficient,inducingdamageandapoptoticce11death.Thecancerce11viabi1itywas1oweredto10.18%aftertreatmentwithPDT.Inaddition,theformationofreactiveoxygenspeciesinHe1ace11safterMFNPs-PDTtreatmentwasstudied,whichsuggestedthatTypeIandTypeIIphotodynamicreactionscanoccursimu1taneous1y.