吡非尼酮联合乙酰半胱氨酸治疗肺纤维化一例并文献复习.docx
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1、此非尼酮联合乙酰半胱氨酸治疗肺纤维化一例并文献复习李文娟张理意周宇麒表1治疗前后肺功能结果变化2.7977.712.392.3865.412.86检查日期2014年9月26日2018年2月26日FVC/L FVC/%|DLCO/ mL/(min mm Hg) J65.668.914.6014.852018 年 10 月 22 日 2.382018 年 12 月 26 日 2.52注:。经BTPS校正;占预计值的百分比;一氧化碳弥散量(DLCO)oSummary目的 评估叱非尼酮与N-乙酰半胱氨酸(NAC)联合治疗肺纤维化的有效性及安全性,为临床用药提供依据。方法收集1例由肺纤维化合并肺气肿综合
2、征(CPFE)发展为特发性肺纤维化(IPF)患者的资料,用“pirfenidone” 及 “N-acetylcysteine” 为 Key 在 Pubmed 数据库中检索,筛选符合标准的文献,提取数据结合有关文献进行回顾性分析。结果患者男,70岁,临床诊断为CPFE进展为IPF, 2018年2月开始使用叱非尼酮联合乙酰半胱氨酸抗纤维化治疗,肺功能指标、CT检查结果均有改善,无明显不良反应,治疗效果良好。共检索到6篇相关文献,其中4篇的研究结果显示叱非尼酮联合NAC治疗肺纤维化效果优于叱非尼酮或NAC单药治疗。另外2篇的研究结果显示叱非尼酮联合NAC治疗患者疾病进展率高于叱非尼酮单药治疗组。结论
3、此非尼酮联合NAC对改善IPF患者肺功能有一定作用,联合治疗可能优于单药治疗。Key肺纤维化;叱非尼酮;N-乙酰半胱氨酸;联合治疗Pirfenidone combined with N-acetylcysteine in treatment of pulmonaryfibrosis: a case report and literature review Li Wenjuan, ZhangLiyi, Zhou Yuqi. Department of Pulmonary and Critical CareMedicine, the Third Affiliated Hospital of Sun
4、 Yat-sen University,Guangzhou 510630, ChinaCorresponding author, Zhou Yuqi, E-mai1: zzyyqqcj7605163. comAbstract Objective To evaluate the efficacy and safety ofpirfenidone combined with N-acetylcysteine (NAC) in the treatmentof pulmonary fibrosis, aiming to provide basis for clinicalmedication. Met
5、hods Clinical data of 1 patient with combinedpulmonary fibrosis and emphysema (CPFE) progressing into idiopathicpulmonary fibrosis (IPF) were reviewed. Relevant literature wassearched and screened from PubMed using the keywords of“pirfenidone” and N-acetylcysteine” . The extracted data andrelevant l
6、iterature were collected for retrospective analysis.Results The male patient, aged 70 years old, was clinicallydiagnosed with CPFE which progressed into IPF. In February, 2018,he was treated with pirfenidone combined with NAC. Pulmonary functionindexes and CT scan data were improved. No significant
7、adverse eventswere observed. High clinical efficacy was achieved. Six studies wereretrieved in this study. The findings in 4 studies showed that theefficacy of pirfenidone combined with NAC was better than that ofmonotherapy in the treatment of pulmonary fibrosis. The results inthe other 2 studies d
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- 吡非尼酮 联合 乙酰 半胱氨酸 治疗 纤维化 文献 复习