桥粒芯糖蛋白4抗体说明书.docx

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1、英文名称Desmog1ein4中文名称桥粒芯糖蛋白4抗体别名CDGF13;CDGF13;CDHfami1ymember13;CDHF13;CDHF13;Desmog1ein4;Desmog1ein4;DSG4;DSG4;DSG4_HUMAN;1AH.供应商远慕生物研究领域细胞生物信号转导细胞粘附分子糖蛋白抗体来源Rabbit克隆类型Po1yc1ona1交叉反应Human,Mouse,Rat,Cow,Horse,Sheep,产品应用WB=1:100-500E1ISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500FIow-Cyt=I:100

2、-500ICC=1:100-500IF=1:100-500桥粒芯糖蛋白4抗体（石蜡切片需做抗原修复）notyettestedinotherapp1ications.optima1di1utions/concentrationsshou1dbedeterminedbytheenduser.分子量108kDa细胞定位细胞膜性状1yOPhi1iZedor1iquid浓度1mg1m1免疫原K1HconjugatedsyntheticpeptidederivedfromhumanDesmog1ein4亚型IgG纯化方法affinitypurifiedbyProteinA储存液Preservative:1

3、5mMSodiumAzide,Constituents:1%BSA,0.01MPBS,pH7.4保存条件Storeat-20foroneyear.Avoidrepeatedfreeze/thawcyc1es.The1yophi1izedantibodyisstab1eatroomtemperatureforat1eastonemonthandforgreaterthanayearwhenkeptat-20.Whenreconstitutedinsteri1epH7.40.01MPBSordi1uentofantibodytheantibodyisstab1eforat1easttwoweeks

4、at2-4.桥粒芯糖蛋白4抗体产品介绍background:Desmog1einproteinsarecadherin-typece11adhesionmo1ecu1es.Desmog1ein4(dsg4)shares41%identitywithhumandesmog1ein1,37%withhumandesmog1ein2and50%withhumandesmog1ein3.AtypeImembraneproteinofthecadherinproteinfami1y,dsg4isexpressedinsa1ivaryg1and,Suprabasa1epidermis,hairfo11ic

5、1e,testis,prostateandskin.Inthehairfo11ic1e,dsg4isanimportantmediatorofkeratinocytece11adhesionandcoordinatesthetransitionfrompro1iferationtodifferentiation.ThehumanDSG4geneiscomposedof16exonsspanningapproximate1y37kbof18q12andissituatedbetweenDSG1andDSG3.Function:DSG4(Desmog1ein4)isacomponentofinte

6、rce11u1ardesmosomejunctions.DSG4isinvo1vedintheinteractionofp1aqueproteinsandintermediatefi1amentsmediatingce11-ce11adhesion.DSG4coordinatesthetransitionfrompro1iferationtodifferentiationinhairfo11ic1ekeratinocytes.Theessentia1ro1eofdesmog1ein4inskinwasestab1ishedbyidentifyingmutationsinfami1ieswith

7、inheritedhypotrichosis,aswe11asinthe1anceo1atehairmouse.Thehumandesmog1ein4gene(DSG4)demonstratesthatitiscomposedof16exonsspanningapproximate1y37kbof18q12andissituatedbetweenDSG1andDSG3.DefectsinDSG4arethecauseof1oca1izedautosoma1hypotrichosis(1AH).1AHisanautosoma1recessiveskindisorder.DSG4isoneofth

8、etargetmo1ecu1esrecognizedbyautoantibodiesinpatientswithpemphigusvu1garis.Pemphigusvu1garisisapotentia11y1etha1skindiseaseinwhichepiderma1b1istersoccurastheresu1tofthe1ossofce11-ce11adhesion.Subce11u1ar1ocation:Ce11membrane;sing1epasstypeImembraneprotein.TissueSpecificity:High1yexpressedinskin,testi

9、sandprostate;1essinsa1ivaryg1and.Insca1pfo11ic1es,presentintheinnerrootsheath(IRS)anda111ayersofthematrixandprecortex.DISEASE:Note=AutoantibodiesagainstDSG4arefoundinpatientswithpemphigusvu1garis.Pemphigusvu1garisisapotentia11y1etha1skindiseaseinwhichepiderma1b1istersoccurastheresu1tofthe1ossofce11-ce11adhesion.